Composição química e aminogramas de cultivares de milho em melhoramento genético.

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Comportamento de triticale e trigo dos cerrados brasileiros na moagem e na produção industrial de pães, biscoitos, bolos e massas alimentícias.

Foram caracterizados os comportamentos de triticale e de trigo, procedentes dos cerrados brasileiros, na moagem e a qualidade das farinhas na produção industrial de pães, biscoitos, bolos e massas alimentícias. O triticale (P. H. 73,2) foi moído sem condicionamento, obtendo-se 72,6% de extração sendo 39,0% de farinha especial e 61,0% de farinha comum. O trigo (P.H. 77,9) foi moído com 15% de umidade, obtendo-se 76,5% de extração sendo 42,6% de farinha especial e 57,4% de farinha comum. Os tempos de moagem/ton de grãos foram praticamente iguais. Pão francês, com 10 ou 20% de farinha de triticale, apresentou qualidade igual ao padrão elaborado semente com farinha de trigo comercial. Pão industrial tipo americano fabricado com 80% de farinha de trigo e 20% de triticale foi considerado bom quando se reduziu o tempo de fermentação. Foram fabricados biscoitos fermentados, salgados, doces secos e amanteigados e concluiu-se que em qualquer um destes tipos pode-se utilizar exclusivamente farinha de triticale ou de trigo dos cerrados, sendo que os biscoitos de triticale, quando comparados com o padrão industrial, apresentaram-se sempre iguais ou superiores. Bolos, com 50% de farinha de triticale e de farinha de triticale, foram considerados superiores, quanto ao sabor, em relação ao padrão industrial. Produziram-se massas alimentícias do tipo espaguete e ninho, com 20% de farinha de triticale e 80% de farinha de trigo especial (cerrados). Os tempos de cozimento, para os dois tipos de massa, foram iguais ao do padrão industrial. Quanto ao aumento de peso e volume, pelo cozimento, os espaguetes não apresentaram diferença, enquanto que, para o tipo ninho, houve diminuição significativa quando se usou farinha de triticale.bitstream/item/65366/1/CTAA-DOCUMENTOS-04-BOLETIM-DE-PESQUISA-NUMERO-004-COMPORTAMENTODE-TRITICALE-E-TRIGO-DOS-CERRADOS-.pd

Comparing the Prevalence of Polypharmacy and Potential Drug-Drug Interactions in Nursing Homes and in the Community Dwelling Elderly of Emilia Romagna Region

Backround: We aimed at assessing the prevalence of polypharmacy and potential drug-drug interactions (DDIs) with clinical relevance in elderly patient on Emilia Romagna area. Both outpatients and residents in nursing homes were assessed, with only partially overlapping strategies. Methods: We defined a list of 190 pairs of potentially interacting drugs, based on literature appraisal and availability of therapeutic alternatives. January-June 2018 data on drug use in patients over 65 years-old were collected from nine Local Health Authorities of Emilia Romagna: data on community-dwelling subjects were extracted from archives of reimbursed prescriptions, while drug use in a sample of nursing homes was recorded from clinical charts in one index day within the same semester. The frequency of polypharmacy (at least five or at least 10 concurrent drugs) and of each DDI was calculated. Results: In line with different rates of polypharmacy (80% vs 16%), the risk of exposure to at least one interaction was 53.7% in nursing homes and 26.4% in outpatients. Among DDIs, in nursing homes antidepressants—anxiolytics (11.9%) ranked first, followed by antidepressants—aspirin (7.4%). In outpatients, ACE-inhibitors—non-steroidal anti-inflammatory drugs (NSAIDs) reached 7.2% followed by the calcium channel blockers—α-blockers (2.4%). Discussion: Polypharmacy and risk of DDIs appeared very different in the two settings, due to both technical and clinical reasons. In order to reduce use of benzodiazepines, NSAIDs, antidepressants and relevant DDIs, 1) defining alternative options for pain relief in elderly outpatients, and 2) implementing non-pharmacological management of insomnia and anxiety in nursing homes should be prioritized

The molecular logic of endocannabinoid signalling

The endocannabinoids are a family of lipid messengers that engage the cell surface receptors that are targeted by Δ9-tetrahydrocannabinol, the active principle in marijuana (Cannabis). They are made on demand through cleavage of membrane precursors and are involved in various short-range signalling processes. In the brain, they combine with CB1 cannabinoid receptors on axon terminals to regulate ion channel activity and neurotransmitter release. Their ability to modulate synaptic efficacy has a wide range of functional consequences and provides unique therapeutic possibilities. © 2003, Nature Publishing Group. All rights reserved

A complex case of right coronary artery chronic total occlusion treated by a successful multi-step Japanese approach

Percutaneous revascularization of coronary chronic total occlusion remains a challenge for the interventional cardiologist. Operator experience and specific tips and tricks for more difficult cases are needed to obtain procedural success in the majority of situations. We describe a case of successful reopening of a chronically occluded right coronary artery using a retrograde wire as a landmark of the true lumen and a novel penetration device (Tornus, Ashai) to facilitate balloon and stent deployment